3D Bioprinting in Osteoarticular Reconstruction: State of the Art and Clinical Perspectives
DOI:
https://doi.org/10.5281/zenodo.21366781Keywords:
3D bioprinting, Tissue engineering, Osteoarticular reconstruction, Regenerative medicine, OrthopedicsAbstract
Three-dimensional (3D) bioprinting has emerged as one of the leading technologies in regenerative medicine, enabling the fabrication of personalized biological tissues through the controlled deposition of living cells, biomaterials, and bioactive molecules. This review aimed to analyze the scientific evidence regarding the applications of 3D bioprinting in osteoarticular reconstruction, focusing on technological advances, clinical applications, benefits, limitations, and future perspectives. An integrative literature review was conducted using PubMed/MEDLINE, Scopus, and Web of Science, including studies published between 2020 and 2026. The selected studies demonstrated promising applications in bone regeneration, cartilage reconstruction, osteochondral defect repair, meniscal tissue engineering, and the development of personalized grafts. The main advantages include high anatomical precision, implant customization, improved tissue integration, and the potential to optimize surgical outcomes. However, challenges related to tissue vascularization, mechanical properties of biomaterials, bioink standardization, regulatory issues, and clinical validation still limit widespread clinical implementation. In conclusion, 3D bioprinting has significant potential to transform osteoarticular reconstruction and represents a promising strategy for the future of regenerative orthopedics and personalized medicine.
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Copyright (c) 2026 Loren Alves Castilho Pereira
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