Non-Invasive Biomarkers for Predicting Clinical Deterioration in Hospitalized Pediatric Patients: A Literature Review
DOI:
https://doi.org/10.5281/zenodo.23287467Keywords:
Clinical Deterioration, Biomarkers, Pediatrics, Physiological Monitoring, Risk PredictionAbstract
Introduction: Clinical deterioration in hospitalized pediatric patients may be preceded by changes in physiological parameters and biomarkers, whose early identification is essential to guide timely interventions. Objective: To analyze the scientific evidence on non-invasive biomarkers and physiological parameters used to predict clinical deterioration in hospitalized pediatric patients. Methods: A literature review was conducted focusing on studies addressing vital signs, laboratory biomarkers, continuous monitoring, and predictive models applied to hospitalized pediatric populations. Results: The studies highlighted the relevance of heart rate, respiratory rate, peripheral oxygen saturation, blood pressure, and peripheral perfusion, particularly when assessed longitudinally and in combination. Machine learning models demonstrated potential to improve the discrimination of deterioration events, while laboratory biomarkers showed utility in specific contexts, such as infections and organ dysfunction. Conclusion: Predicting clinical deterioration in pediatric patients benefits from integrating physiological parameters, biomarkers, and predictive tools. Prospective multicenter studies are needed to validate these strategies and determine their impact on clinical decision-making and hospital outcomes.
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Copyright (c) 2026 Beatriz Santos Ferreira Bagano Campos, Ana Hisi Fujii Ramos, Larah Luyza Canale Medeiros, Eduardo Bottan Rocha
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